Coaching classes consisted of three to six cycles. Drug education entailed infusion of ?nine-THC (0.one mg/kg i.v.) or rimonabant (one mg/kg i.v.) in the primary moment of the first of three cycles; sham (dull pressure applied to the pores and skin overlying the vascular access port) was administered in the 1st minute of the following cycles. Auto
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Competitors binding experiments done in CHO cell membranes transfected with human CB1 or CB2 receptors disclosed affinity values while in the low nanomolar assortment for both of those the tested compounds AM-2201 and MAM-2201 (Table 1). Similar results were being obtained assessing affinity values of the two synthetic cannabinoids in mouse tissues